F2 Stress + Mood

ONLY FOR REGION: INTERNATIONAL

 144.99

30 day supply

DR PRUSS®  F2 formula helps regulate all neurotransmitter systems, including those of serotonin, dopamine and GABA.

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Product Benefits

The neurotransmitters dopamine, serotonin, GABA, and melatonin are all key neurotransmitters in the brain. Dopamine is known as the “feel-good” chemical, as it creates a sensation of pleasure and reward. Low levels of serotonin have been associated with anxiety and depression. GABA, or gamma-aminobutyric acid, helps regulate the overactivity of neurons when the body is exposed to stress. And melatonin helps aid the body’s sleep cycle while also lowering levels of cortisol, the stress hormone.  So together, these four chemicals have a powerful impact over depression, mood swings, anxiety and sleep disturbances.

Many drugs act, in particular, on the reuptake of serotonin in order to maintain a state of well-being or control. We have selected an extract of Griffonia particularly rich in 5-HTP, the direct precursor of serotonin.

In parallel, we added L-theanine, which helps reduce mental and physical stress, and promotes a relaxing effect on the brain. It also improves attention and promotes the production of GABA, as well as the concentration of serotonin and dopamine.

Other ingredients include magnesium, which is coupled to glycine for its muscle relaxant properties, and tyrosine, which acts as a precursor to dopamine.

Sweet orange extract acts as an anxiolytic, or anxiety reducer, and its administration has resulted in a decrease in salivary cortisol levels. Ashwagandha is included for its anxiolytic (anxiety-reducing) and anti-stress effect, measured by the Hamilton (HAM-A Hamilton Anxiety Rating Scale), and DASS-21 (Depression, Anxiety, and Stress Scale -21) scales, resulting in a reduction in stress hormones (cortisol in particular).

Saffron acts as a natural antidepressant. Crocin (from the Crocus sativus (L.) is said to inhibit the reuptake of dopamine and norepinephrine, while safranal, the aromatic compound from the saffron herb, does the same to serotonin. By inhibiting reuptake, it ensures that the receptors get the amount they need.

Lemon balm is an anxiolytic sedative which acts on GABA-ergic receptors, inhibits the activity of gamma-aminobutyric acid transaminase (GABA-transaminase), and increases the level of GABA in the brain by inhibiting its catabolism. It also helps to act positively on nervousness, insomnia and anxiety.

Validation

EFSA Health Claims:

  • Magnesium contributes to:
    • a reduction of tiredness and fatigue
    • electrolyte balance
    • normal energy-yielding metabolism
    • normal functioning of the nervous system
    • normal muscle function
    • normal protein synthesis
    • normal psychological function
    • the maintenance of normal bones
    • the maintenance of normal teeth
  • Magnesium has a role in the process of cell division.

References

L-Theanine

  • Gomez-Ramirez M, Higgins BA, Rycroft JA, Owen GN, Mahoney J, Shpaner M, Foxe JJ. The deployment of intersensory selective attention: a high-density electrical mapping study of the effects of theanine. Clin Neuropharmacol. 2007 Jan-Feb;30(1):25-38.
  • Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007 Jan;74(1):39-45. Epub 2006 Aug 22.
  • Nathan PJ, Lu K, Gray M, Oliver C. The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. J Herb Pharmacother. 2006;6(2):21-30.

Saffron extract

  • Karimi G, Hosseinzadeh H, Khaleghpanah P, 2001. Study of antidepressant effect of aqueous and ethanolic extract of Crocus sativus in mice. Irn.J.BasicMed.Sci. 4,11–15.
  • Amin B, Nakhsaz A, Hosseinzadeh H. Evaluation of the antidepressant-like effects of acute and sub-acute administration of crocin and crocetin in mice. Avicenna Journal of Phytomedicine. 2015;5(5):458-468.
  • Hosseinzadeh H, Karimi G and Niapoor M. 2004. Antidepressant effect of Crocus sativus L. stigma extracts and their constiutents, crocin and safranal in mice. Acta Hort. (ISHS) 650:435-445

Ashwagandha

  • Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2019 Sep;98(37):e17186. doi: 10.1097/MD.0000000000017186.

Melissa officinalis

  • Kennedy DO, Little W, Scholey AB. Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm). Psychosom Med. 2004 Jul-Aug;66(4):607-13.
  • Ibarra A, Feuillere N, Roller M, Lesburgere E, Beracochea D. Effects of chronic administration of Melissa officinalis L. extract on anxiety-like reactivity and on circadian and exploratory activities in mice. Phytomedicine. 2010 May;17(6):397-403.
  • Julien Cases, Alvin Ibarra, Nicolas Feuillère, Marc Roller, Samir G. Sukkar. Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Mediterr J Nutr Metab (2011) 4:211–218

Sweet orange extract

  • Faturi CB, Leite JR, Alves PB, Canton AC, Teixeira-Silva F. Anxiolytic-like effect of sweet orange aroma in Wistar rats. Prog Neuropsychopharmacol Biol Psychiatry. 2010 May 30;34(4):605-9. doi: 10.1016/j.pnpbp.2010.02.020.
  • Jafarzadeh M, Arman S, Pour FF. Effect of aromatherapy with orange essential oil on salivary cortisol and pulse rate in children during dental treatment: A randomized controlled clinical trial. Adv Biomed Res. 2013 Mar 6;2:10. doi: 10.4103/2277-9175.107968.

Magnesium

  • Schwalfenberg GK, Genuis SJ. The Importance of Magnesium in Clinical Healthcare. Scientifica (Cairo). 2017;2017:4179326. doi:10.1155/2017/4179326

Supplement facts

SUPPLEMENT FACTS
Serving Size: 1 Vial
Servings per Container: 30

AMOUNT PER SERVING % Daily Value
Magnesium (from magnesium bisglycinate) 300 mg 71%
L-Tyrosine (Free-Form) 200 mg **
L-Theanine (Suntheanine®) 150 mg **
5-HTP (from Griffonia simplicifolia seeds) 75 mg **
Lemon balm extract (from leaves of Melissa officinalis (L.)) (Bluenesse®) 75 mg **
Phosphatidylserine (Sharp PS Green®) 75 mg **
Saffron Extract (from stigma of Crocus sativus (L.)) (Satiereal®) 50 mg **
Asparagus Extract (from stem of Asparagus officinalis) (ETAS®) 35 mg **
Ashwagandha Extract (from leaves and roots of Withania somnifera) (Sensoril®) 10 mg **
Sweet Orange Extract (from peel of Citrus sinensis) 10 mg **

** Daily Value not established.

Directions: As a dietary supplement for adults, consume one (1) vial daily, in the morning 30 minutes before breakfast, or as recommended by a healthcare practitioner. Mix with 8 oz./250 ml (one glass) of water.