F6 Methylation + Active-B Complex

ONLY FOR REGION: INTERNATIONAL

 133.99

30 day supply

DR PRUSS®  F6 formula was created to help support the body’s methylation cycle. Optimal methylation positively impacts the biochemical processes that regulate the cardiovascular, neurological, detoxification and reproductive systems, among others.

Excess homocysteine levels have been associated with cardiovascular disease and stroke, dementia, and osteoporosis. This formula’s active forms of folate, betaine, B6, and B12 contribute to normal homocysteine metabolism. Detoxifying the body of excess homocysteine helps protect it from chronic diseases and support the methylation cycle.

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Product Benefits

The methylation cycle begins with folate. When methyl tetrahydrofolate reductase (MTHFR) acts on folate, it picks up a methyl group, transforming into methyl tetrahydrofolate (MTHF). MTHF helps to break down the potentially harmful amino acid, homocysteine, and convert it to methionine, an important and beneficial amino acid.

Homocysteine is an amino acid that is a biproduct of the methylation cycle, but it can also be accumulated through various external factors such as excess alcohol or coffee consumption, smoking, or poor diet. Detoxifying the body of excess homocysteine can help protect it from chronic and cardiovascular diseases, stroke, dementia, and osteoporosis.

Betaine is found in most living organisms and helps manage the buildup of homocysteine in the blood. Elevated homocysteine can lead to atherosclerosis and stroke. Betaine helps manage the conversion of homocysteine to methionine, which helps to build strong bones and maintain a healthy liver.

The trio of B vitamins – B2, B6, and folic acid – also help manage homocysteine levels. Vitamin B2 helps maintain the body’s energy supply by converting carbohydrates into adenosine triphosphate (ATP), a compound which helps boost metabolism by transporting energy between cells.

Magnesium carries a myriad of benefits, including healthy bone formation, cardiovascular support, healthy muscle maintenance, and management of  head cavity discomfort.

Validation

EFSA Health Claims:

  • Betaine contributes to normal homocysteine metabolism. The beneficial effect is obtained with a daily intake of 1,5 g of betaine. A daily intake in excess of 4 g may significantly increase blood cholesterol levels.
  • Folate contributes to:
    • maternal tissue growth during pregnancy
    • normal amino acid synthesis
    • normal blood formation
    • normal homocysteine metabolism
    • normal psychological function
    • normal function of the immune system
    • reduction of tiredness and fatigue
  • Folate has a role in the process of cell division
  • Riboflavin contributes to:
    • normal energy-yielding metabolism
    • normal functioning of the nervous system
    • maintenance of normal mucous membranes
    • maintenance of normal red blood cells
    • maintenance of normal skin
    • maintenance of normal vision
    • normal metabolism of iron
    • protection of cells from oxidative stress
    • reduction of tiredness and fatigue
  • Vitamin B12 contributes to:
    • normal energy-yielding metabolism
    • normal functioning of the nervous system
    • normal homocysteine metabolism
    • normal psychological function
    • normal red blood cell formation
    • normal function of the immune system
    • reduction of tiredness and fatigue
  • Vitamin B12 has a role in the process of cell division
  • Vitamin B6 contributes to:
    • normal cysteine synthesis
    • normal energy-yielding metabolism
    • normal functioning of the nervous system
    • normal homocysteine metabolism
    • normal protein and glycogen metabolism
    • normal psychological function
    • normal red blood cell formation
    • normal function of the immune system
    • reduction of tiredness and fatigue
    • regulation of hormonal activity
  • Magnesium contributes to:
    • a reduction of tiredness and fatigue
    • electrolyte balance
    • normal energy-yielding metabolism
    • normal functioning of the nervous system
    • normal muscle function
    • normal protein synthesis
    • normal psychological function
    • the maintenance of normal bones
    • the maintenance of normal teeth
  • Magnesium has a role in the process of cell division.

References

Methylcobalamin

  1. Maron BA, Loscalzo J. The treatment of hyperhomocysteinemia. Annu Rev Med. 2009;60:39-54. doi:10.1146/annurev.med.60.041807.123308
  2. Trimarchi H, Schiel A, Freixas E, Díaz M. Randomized trial of methylcobalamin and folate effects on homocysteine in hemodialysis patients. Nephron. 2002;91(1):58-63. doi:10.1159/000057605

Folates

  1. Brustolin S, Giugliani R, Félix TM. Genetics of homocysteine metabolism and associated disorders. Braz J Med Biol Res. 2010;43(1):1-7. doi:10.1590/s0100-879×2009007500021
  2. Miller AL. The methylation, neurotransmitter, and antioxidant connections between folate and depression. Altern Med Rev. 2008;13(3):216-226.
  3. Mahmoud AM, Ali MM. Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outcome. Nutrients. 2019;11(3):608. Published 2019 Mar 13. doi:10.3390/nu11030608

Betaine

  1. Obeid R. The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway. Nutrients. 2013;5(9):3481-3495. Published 2013 Sep 9. doi:10.3390/nu5093481
  2. Zeisel S. Choline, Other Methyl-Donors and Epigenetics. Nutrients. 2017;9(5):445. Published 2017 Apr 29. doi:10.3390/nu9050445

Riboflavin

  1. Lathrop Stern L, Shane B, Bagley PJ, Nadeau M, Shih V, Selhub J. Combined marginal folate and riboflavin status affect homocysteine methylation in cultured immortalized lymphocytes from persons homozygous for the MTHFR C677T mutation. J Nutr. 2003;133(9):2716-2720. doi:10.1093/jn/133.9.2716

B complex

  1. Liu Z, Choi SW, Crott JW, Smith DE, Mason JB. Multiple B-vitamin inadequacy amplifies alterations induced by folate depletion in p53 expression and its downstream effector MDM2. Int J Cancer. 2008;123(3):519-525. doi:10.1002/ijc.23599

Magnesium

  1. Remely M, Lovrecic L, de la Garza AL, et al. Therapeutic perspectives of epigenetically active nutrients. Br J Pharmacol. 2015;172(11):2756-2768. doi:10.1111/bph.12854

Supplement facts

SUPPLEMENT FACTS
Serving Size: 1 Vial
Servings per Container: 30

AMOUNT PER SERVING % Daily Value
Riboflavin (Vitamin B2, as riboflavin 5’-Phosphate Sodium) 23.6 mg 1815%
Vitamin B6 (as Pyridoxal 5’-Phosphate) 10 mg 588%
Folate (as L-5-Methyltetrahydrofolate) 1000 mcg 250%
Vitamin B12 (as Methylcobalamin) 1000 mcg 41667%
Betaine anhydrous (Trimethyl glycine) 750 mg **
Magnesium (as Citrate-Malate) 400 mg 95%

** Daily Value not established.

Directions: As a dietary supplement for adults, consume one (1) vial daily, in the morning during or after breakfast, or as recommended by a healthcare practitioner. Mix with 8 oz./250 ml (one glass) of water.