F35 Cholesterol + Blood Pressure

ONLY FOR REGION: USA

$ 75.99

30 day supply

Cardiovascular disease is the leading cause of death worldwide, and one of the biggest risk factors is atherosclerosis. DR PRUSS® F35 formula is a bioactive complex based on Centella asiatica and Resveratrol, both of which have shown positive effects on the stability of atherosclerotic plaques, as well as on inflammatory markers.

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Product Benefits

Centella asiatica has been used as a medicinal herb to accelerate the healing of burns by antioxidant effect, to stimulate the biosynthesis of collagen, and to improve the stability of atherosclerotic plaques.

Resveratrol improves life expectancy by activating sirtuins (proteins that regulate cellular health) and sirtuin 1 (SIRT1) molecules, by inhibiting the proliferation of vascular smooth muscle cells, and by reducing mitochondrial oxidative stress. Resveratrol has also been shown to help prevent metabolic syndrome, improve glucose tolerance, and protect the vascular walls and coronaries against oxidation, inflammation, and the formation of thrombi.

We have added policosanol, the reported effects of which are numerous, namely cholesterol lowering properties, improvement of lipid status, reduction of LDL oxidation, and decrease in platelet aggregation.

Finally, nattokinase has a myriad of cardiovascular benefits, from blood pressure management to reduction in incidence of deep vein thrombosis (DVT). Nattokinase also helps reduce atherosclerosis (hardening of the arteries) by reducing arterial plaque and improves circulation.

References

Policonasol

  • Cho KH, Kim SJ, Yadav D, Kim JY, Kim JR. Consumption of Cuban Policosanol Improves Blood Pressure and Lipid Profile via Enhancement of HDL Functionality in Healthy Women Subjects: Randomized, Double-Blinded, and Placebo-Controlled Study. Oxid Med Cell Longev. 2018;2018:4809525. Published 2018 Apr 16. doi:10.1155/2018/4809525
  • Castaño G, Mas R, Fernández L, Illnait J, Gámez R, Alvarez E. Effects of policosanol 20 versus 40 mg/day in the treatment of patients with type II hypercholesterolemia: a 6-month double-blind study. Int J Clin Pharmacol Res. 2001;21(1):43-57.
  • Menendez R, Fernandez SI, Del Rio A, et al. Policosanol inhibits cholesterol biosynthesis and enhances low density lipoprotein processing in cultured human fibroblasts. Biol Res. 1994;27(3-4):199-203.

Resveratrol

  • McCubrey JA, Lertpiriyapong K, Steelman LS, et al. Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs. Aging (Albany NY). 2017;9(6):1477-1536. doi:10.18632/aging.101250
  • Araim O, Ballantyne J, Waterhouse AL, Sumpio BE. Inhibition of vascular smooth muscle cell proliferation with red wine and red wine polyphenols. J Vasc Surg. 2002;35(6):1226-1232. doi:10.1067/mva.2002.124358
  • Ungvari Z, Labinskyy N, Mukhopadhyay P, et al. Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells. Am J Physiol Heart Circ Physiol. 2009;297(5):H1876-H1881. doi:10.1152/ajpheart.00375.2009
  • Bradamante S, Barenghi L, Villa A. Cardiovascular protective effects of resveratrol. Cardiovasc Drug Rev. 2004;22(3):169-188. doi:10.1111/j.1527-3466.2004.tb00139.x
  • Araim O, Ballantyne J, Waterhouse AL, Sumpio BE. Inhibition of vascular smooth muscle cell proliferation with red wine and red wine polyphenols. J Vasc Surg. 2002;35(6):1226-1232. doi:10.1067/mva.2002.124358
  • Liu L, Wang Y, Lam KS, Xu A. Moderate wine consumption in the prevention of metabolic syndrome and its related medical complications. Endocr Metab Immune Disord Drug Targets. 2008;8(2):89-98. doi:10.2174/187153008784534385

Centella asiatica

  • Lee J, Jung E, Kim Y, et al. Asiaticoside induces human collagen I synthesis through TGFbeta receptor I kinase (TbetaRI kinase)-independent Smad signaling. Planta Med. 2006;72(4):324-328. doi:10.1055/s-2005-916227
  • Luzzi R, Belcaro G, Ippolito E. Carotid plaque stabilization induced by the supplement association Pycnogenol® and centella asiatica (Centellicum®). Minerva Cardioangiol. 2016;64(6):603-609.
  • Belcaro G, Dugall M, Ippolito E, et al. Pycnogenol® and Centella asiatica to prevent asymptomatic atherosclerosis progression in clinical events. Minerva Cardioangiol. 2017;65(1):24-31. doi:10.23736/S0026-4725.16.04008-1
  • Belcaro G, Ippolito E, Dugall M, et al. Pycnogenol® and Centella asiatica in the management of asymptomatic atherosclerosis progression. Int Angiol. 2015;34(2):150-157.
  • Punturee K, Wild CP, Vinitketkumneun U. Thai medicinal plants modulate nitric oxide and tumor necrosis factor-alpha in J774.2 mouse macrophages. J Ethnopharmacol. 2004;95(2-3):183-189. doi:10.1016/j.jep.2004.06.019

Nattokinase

  • Chen H, McGowan EM, Ren N, et al. Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. Biomark Insights. 2018;13:1177271918785130. Published 2018 Jul 5. doi:10.1177/1177271918785130
  • Weng Y, Yao J, Sparks S, Wang KY. Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease. Int J Mol Sci. 2017;18(3):523. Published 2017 Feb 28. doi:10.3390/ijms18030523
  • Kurosawa, Y., Nirengi, S., Homma, T. et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles.Sci Rep 5, 11601 (2015). https://doi.org/10.1038/srep11601

Supplement facts

SUPPLEMENT FACTS
Serving Size: 2 Capsules
Servings per Container: 30

AMOUNT PER SERVING % Daily Value
Centella asiatica (leaf extract) 500 mg **
Resveratrol (transresveratrol from Polygonum cuspidatum extract) 100 mg 111%
Nattokinase (2000 FUs) (enzyme from Natto Extract) (Non-GMO soy derived) 100 mg **
Policosanol 20 mg **

Directions: As a dietary supplement for adults, consume two (2) capsules daily in the morning, 30 minutes before breakfast, or as recommended by a healthcare practitioner.