F1 Energy + Focus

ONLY FOR REGION: INTERNATIONAL

 172.99

30 day supply

DR PRUSS®  F1 formula contains clinically measured potencies of ingredients specifically designed to provide mitochondrial support, including pyroquinolonequinone (PQQ), ubiquinol CoQ10, and nicotinamide (NADH).

Mitochondria are tiny structures within our cells which convert the nutrients we consume into usable energy. In short, they are the powerhouses of our body. By increasing their energy output, we increase our own.

In addition, our formula contains a select blend of adaptogenic plants such as mucuna pruriens and bacopa to support the production of beneficial neurotransmitters such as dopamine and seratonin, both of which are essential for proper brain function and mood.

All pictures shown are for illustration purpose only, actual product may vary due to product enhancement.
 

Product Benefits

Energy and Mitochondrial Support

PQQ is a nutrient which has been found to help generate new mitochondria in the body (mitochondrial biogenesis). Given that mitochondria generate the energy that cells need to survive, the production of new mitochondria is hugely impactful.

Ubiquinol CoQ10 helps to turbocharge PQQ, making this combination of ingredients extremely effective. It is also one of the most powerful antioxidants available.

NADH is found in all living cells and is central to mitochondrial function. It is a critical contributor to the production of adenosine triphosphate (ATP), a molecule which carries and transports energy within all cells.

Rhodiola improves physical and mental performance, but also increases serotonin and dopamine levels by lowering the level of COMT (catechol-O-methyltransferase, which degrades serotonin and dopamine). It ultimately helps the body to better respond to stressful situations, both mentally and physically.

Bacopa extract modulates the production of glutamate, an amino acid which functions as perhaps the most important neurotransmitter in the brain, while increasing levels of GABA and serotonin, two important neurotransmitters that are associated with mood. Studies have shown an improvement in cognitive abilities in humans after administration of Bacopa monnieri extract.

Creatine provides muscles with energy. In addition to athletic and exercise improvement, research has shown that creatine supplementation not only improves exercise performance, but plays a role in recovery, as well.

Ginkgo biloba has been shown to improve cognitive function by increasing the uptake of glucose and oxygen by the brain, while magnesium contributes to higher mental focus, improves, and helps to regulate sleep and manage anxiety

Validation

EFSA Health Claims:

  • Magnesium contributes to:
    • a reduction of tiredness and fatigue
    • electrolyte balance
    • normal energy-yielding metabolism
    • normal functioning of the nervous system
    • normal muscle function
    • normal protein synthesis
    • normal psychological function
    • the maintenance of normal bones
    • the maintenance of normal teeth
  • Magnesium has a role in the process of cell division.

References

Rhodiola extract

  • Panossian A, Wikman G. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol. 2009 Sep;4(3):198-219.
  • Abidov M, Crendal F, Grachev S, Seifulla R, Ziegenfuss T. Effect of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of skeletal muscles. Bull Exp Biol Med. 2003 Dec;136(6):585-7
  • Krajewska-Patan A., Dreger M., Lowicka A., Gorska-Paukszta M., Mscisz A., Mikolajczak P.L., Buchwald W., Furmanowa M., Mrozikiewicz P.M. Preliminary pharmacological investigations of biotransformed roseroot [Rhodiola rosea L.] callus tissue. Herba Polonica. 2008. 54 (3)
  • Shevtsov VA, Zholus BI, Shervarly VI, Vol’skij VB, Korovin YP, Khristich MP, Roslyakova NA, Wikman G. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine. 2003 Mar;10(2-3):95-105.
  • Olsson EM, von Schéele B, Panossian AG. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med. 2009 Feb;75(2):105-12.

Bacopa extract

  • Paulose CS, Chathu F, Khan SR, Krishnakumar A. Neuroprotective role of Bacopa monnieri extract in epilepsy and effect of glucose supplementation during hypoxia: glutamate receptor gene expression. Neurochem Res. 2008 Sep;33(9):1663-71.
  • Stough C, Downey LA, Lloyd J, Silber B, Redman S, Hutchison C, Wesnes K, Nathan PJ. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial. Phytother Res. 2008 Dec;22(12):1629-34. doi: 10.1002/ptr.2537.
  • Downey LA, Kean J, Nemeh F, Lau A, Poll A, Gregory R, Murray M, Rourke J, Patak B, Pase MP, Zangara A, Lomas J, Scholey A, Stough C. An acute, double-blind, placebo-controlled crossover study of 320 mg and 640 mg doses of a special extract of Bacopa monnieri (CDRI 08) on sustained cognitive performance. Phytother Res. 2013 Sep;27(9):1407-13. doi: 10.1002/ptr.4864.

Ginkgo

  • Cieza A, Maier P, Pöppel E. Effects of Ginkgo biloba on mental functioning in healthy volunteers. Arch Med Res. 2003 Sep-Oct;34(5):373-81
  • Defeudis FV. Bilobalide and neuroprotection. Pharmacol Res. 2002 Dec;46(6):565-8.

PQQ

  • Chowanadisai W, Bauerly KA, Tchaparian E, Wong A, Cortopassi GA, Rucker RB. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. J Biol Chem. 2010;285(1):142-152. doi:10.1074/jbc.M109.030130
  • Lu J, Chen S, Shen M, et al. Mitochondrial regulation by pyrroloquinoline quinone prevents rotenone-induced neurotoxicity in Parkinson’s disease models. Neurosci Lett. 2018;687:104-110. doi:10.1016/j.neulet.2018.09.031
  • Harris CB, Chowanadisai W, Mishchuk DO, Satre MA, Slupsky CM, Rucker RB. Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects. J Nutr Biochem. 2013;24(12):2076-2084. doi:10.1016/j.jnutbio.2013.07.008

COQ10

  • Lenaz G, Fato R, Castelluccio C, et al. The function of coenzyme Q in mitochondria. Clin Investig. 1993;71(8 Suppl):S66-S70. doi:10.1007/BF00226843

NADH

  • Nicolson GL. Mitochondrial Dysfunction and Chronic Disease: Treatment With Natural Supplements. Integr Med (Encinitas). 2014;13(4):35-43.

Magnesium

  • Schwalfenberg GK, Genuis SJ. The Importance of Magnesium in Clinical Healthcare. Scientifica (Cairo). 2017;2017:4179326. doi:10.1155/2017/4179326

Creatine

  • Rawson ES, Stec MJ, Frederickson SJ, Miles MP. Low-dose creatine supplementation enhances fatigue resistance in the absence of weight gain. Nutrition. 2011;27(4):451-455. doi:10.1016/j.nut.2010.04.001

Mucuna pruriens

  • Shukla KK, Mahdi AA, Ahmad MK, Jaiswar SP, Shankwar SN, Tiwari SC. Mucuna pruriens Reduces Stress and Improves the Quality of Semen in Infertile Men. Evid Based Complement Alternat Med. 2010;7(1):137-144. doi:10.1093/ecam/nem171
  • Rana DG, Galani VJ. Dopamine mediated antidepressant effect of Mucuna pruriens seeds in various experimental models of depression. Ayu. 2014 Jan;35(1):90-7. doi: 10.4103/0974-8520.141949.

Supplement facts

SUPPLEMENT FACTS
Serving Size: 1 Vial
Servings per Container: 30

AMOUNT PER SERVING % Daily Value
Creatine (monohydrate form) 1000 mg **
Rhodiola rosea (leaf extract) 300 mg **
Magnesium (from magnesium malate) 250 mg 60%
Coenzyme Q10 (Shiro-Q®) 200 mg **
Mucuna pruriens (seeds extract) 200 mg **
Bacopa monieri (leaf extract, 40% Bacosides) 150 mg **
Ginkgo biloba (leaf extract) 150 mg **
NADH (as sodium salt) 20 mg **
PQQ (pyrroloquinoline quinone) (as Micro PQQ®) 10 mg **

** Daily Value not established.

Directions: As a dietary supplement for adults, consume one (1) vial daily, in the morning after breakfast, or as recommended by a healthcare practitioner. Mix with 8 oz./250 ml (one glass) of water.